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Bleomycin Sulfate

Name Bleomycin Sulfate
CAS No. 9041-93-4
Sepcification USP42/EP10
Usage and indications Bleomycin is mostly used to treat cancer.This includes testicular cancer, ovarian cancer, and Hodgkin's disease, and less commonly non-Hodgkin's disease.
Structural formaula

1. Dosage form and Mechanism of action

Dosage form: Injection

Mechanism of action: Bleomycin acts by induction of DNA strand breaks. Some studies suggest bleomycin also inhibits incorporation of thymidine into DNA strands. DNA cleavage by bleomycin depends on oxygen and metal ions, at least in vitro. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. An alternative hypothesis states that bleomycin may bind at specific sites in the DNA strand and induce scission by abstracting the hydrogen atom from the base, resulting in strand cleavage as the base undergoes a Criegee-type rearrangement, or forms an alkali-labile lesion. In addition, these complexes also mediate lipid peroxidation and oxidation of other cellular molecules. Therefore, bleomycin is used in combination with doxorubicin in Hodgkins lymphoma, as they have additive and complementary effects on the DNA, since doxorubicin acts by intercalating between DNA strands, and also acts on topoisomerase II enzyme thus relaxing the topoisomerase complexes.

2. Specification

Regarding the detailed standard, please contact info@shjnj.com

3. Package

100 grams/bag; 500 grams/bag; It can also be packed according to the requirements

4. Product source

Produced by fermentation in China

5. Document support

SMF and DMF are available

6. Supply

    Annual capacity: 10 kgs; Stable supply for more than 15 years

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