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Mycophenolate mofetil

Name Mycophenolate mofetil
CAS No. 115007-34-6
Sepcification USP42
Usage and indications Mycophenolate is used for the prevention of organ transplant rejection. Mycophenolate mofetil is indicated for the prevention of organ transplant rejection in adults and kidney transplantation rejection in children over 2 years; whereas mycophenolate sodium is indicated for the prevention of kidney transplant rejection in adults. Mycophenolate sodium has also been used for the prevention of rejection in liver, heart, or lung transplants in children older than two years
Structural formaula

1. Dosage form and Mechanism of action

Dosage form: Tablets/Capsules

Mechanism of action: Purines (including the nucleotides guanosine and adenosine) can either be synthesized de novo using ribose 5-phosphate or they can be salvaged from free nucleotides. Mycophenolic acid is potent, reversible, non-competitive inhibitor of inosine-5'-monophosphate dehydrogenase (IMPDH), an enzyme essential to the de novo synthesis of guanosine-5'-monophosphate (GMP) from inosine-5'-monophosphate (IMP). IMPDH inhibition particularly affects lymphocytes since they rely almost exclusively on de novo purine synthesis. In contrast, many other cell types use both pathways, and some cells, such as terminally differentiated neurons, depend completely on purine nucleotide salvage. Thus, use of mycophenolic acid leads to a relatively selective inhibition of DNA replication in T cells and B cells.

2. Specification

Regarding the detailed standard, please contact info@shjnj.com

3. Package

10 kgs /bag; It can also be packed according to the requirements

4. Product source

Produced by Chemical synthesis in China

5. Document support

SMF and DMF are available

6. Supply

    Annual capacity: 5000 MT; Stable supply for more than 5 years

If you need, Please contact us:info@shjnj.com

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